SHBG(SHBG)
SHBG binds testosterone, removing it from circulation. High SHBG can mask adequate total T as low free T. Low SHBG often reflects insulin resistance.
Optimal range
15–35nmol/L
Clinical "normal"
10–57 nmol/L
Avg. cost (US)
$45
Test frequency
With total T, every 3–6 months
When to measure
Fasted morning draw, paired with total T.
How to measure
Standard immunoassay.
Average cost
≈ $45 cash price. Often covered by insurance with relevant ICD-10.
Signs your level is off
Symptoms if low
High free T (rare).
Symptoms if high
Low free T despite high TT.
If your level is low
Nettle: mild diuretic
Supplement
Nettle Root· 300 mg/day
Form: Extract
Binds to SHBG, freeing testosterone.
Foods
- Green tea
Lifestyle
- Low-carb diet
Caution: Nettle: mild diuretic
If your level is high
Metformin: GI upset
Supplement
Boron· 10 mg/day
Form: Glycinate
Reduces SHBG production.
Foods
- High-carb diet
Lifestyle
- Balanced diet
Medication (if prescribed)
Metformin· 500-1000 mg/day
Form: Oral tablet
Reference only. Speak with a licensed clinician before any prescription intervention.
Caution: Metformin: GI upset
Test these together
These biomarkers contextualize SHBG and unlock a clearer picture than any single value can.
Deeper reading
Protocols that move this marker
Selected studies
JCEM 2023 PubMed
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